Abstract. The HYDROPTIMET Project, Interreg IIIB EU program, is developed in the framework of the prediction and prevention of natural hazards related to severe hydro-meteorological events and aims to the optimisation of Hydro-Meteorological warning systems by the experimentation of new tools (such as numerical models) to be used operationally for risk assessment. The objects of the research are the mesoscale weather phenomena and the response of watersheds with size ranging from 10² to 10³ km². Non-hydrostatic meteorological models are used to catch such phenomena at a regional level focusing on the Quantitative Precipitation Forecast (QPF). Furthermore hydrological Quantitative Discharge Forecast (QDF) are performed by the simulation of run-off generation and flood propagation in the main rivers of the territory. In this way observed data and QPF are used, in a real-time configuration, for one-way forcing of the hydrological model that works operationally connected to the Piemonte Region Alert System. The main hydro-meteorological events that affected Piemonte Region in the last years are analysed, these are the HYDROPTIMET selected test cases of 14–18 November 2002 and 23–26 November 2002. The results obtained in terms of QPF and QDF offer a basis to evaluate the sensitivity of the whole hydro-meteorological chain to the uncertainties in the numerical simulations. Different configurations of non-hydrostatic meteorological models are also evaluated.