Abstract. This study attempts to achieve real-time rainfall-inundation forecasting in lowland regions, based on a synthetic potential inundation database. With the principal component analysis and a feed-forward neural network, a rainfall-inundation hybrid neural network (RiHNN) is proposed to forecast 1-h-ahead inundation depth as hydrographs at specific representative locations using spatial rainfall intensities and accumulations. A systematic procedure is presented to construct the RiHNN, which combines the merits of detailed hydraulic modeling in flood-prone lowlands via a two-dimensional overland-flow model and time-saving calculation in a real-time rainfall-inundation forecasting via ANN model. Analytical results from the RiHNNs with various principal components indicate that the RiHNNs with fewer weights can have about the same performance as a feed-forward neural network. The RiHNNs evaluated through four types of real/synthetic rainfall events also show to fit inundation-depth hydrographs well with high rainfall. Moreover, the results of real-time rainfall-inundation forecasting help the emergency manager set operational responses, which are beneficial for flood warning preparations.